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首页> 外文OA文献 >Pharmacotherapy of Persons with Dementia in Long-term Care in Australia: A Descriptive Audit of Central Nervous System Medications
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Pharmacotherapy of Persons with Dementia in Long-term Care in Australia: A Descriptive Audit of Central Nervous System Medications

机译：在澳大利亚的长期护理中对痴呆症患者进行药物治疗：对中枢神经系统药物的描述性审核

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Background: Neuropsychiatric symptoms of dementia are often treated through the prescription of one or more psychotropic medications. However, limited efficacy and potential harmful side-effects has resulted in efforts to reduce the use of psychotropic medication in this population, particularly for those living in long-term care.Objectives: This study sought to describe the pattern of central nervous system medication usage in older adults with dementia living in long-term care; assess the appropriateness of prescribing against Beers criteria; and detect potential drug interactions from co-administered medications.Methods: A retrospective descriptive audit of the medical records of n=415 residents, aged >60 years with a diagnosis of dementia, from 28 long-term care facilities in Queensland, Australia. Information extracted included the types and usage of regular and Pro Re Nata central nervous system medications.Results: Of those taking medication (n=317), 68% were prescribed at least one potentially inappropriate medication, and there was a significant positive correlation between the number of medications prescribed and the number of potentially inappropriate medications. Two-hundred potential interactions with variable severity were identified from 130 residents on ≥ 1 medication – 38% were potentially severe interactions, 46% were moderate.Conclusion: This medication audit raises concerns that prescription of medications may still be the first resort to treat behavioural and psychological symptoms of dementia. There is a need for effective and sustainable person-centred interventions that address barriers for appropriate prescribing practice, and involve the collaboration of all healthcare professionals to optimise prescribing and improve the quality of medicines in older people with dementia.
机译：背景：痴呆症的神经精神症状通常通过一种或多种精神药物的处方来治疗。然而，有限的疗效和潜在的有害副作用导致人们努力减少该人群中精神药物的使用，特别是对于那些长期护理的人群。目的：本研究旨在描述中枢神经系统药物的使用方式在老年痴呆症中长期生活的成年人；评估处方比尔斯标准的适当性；方法：对来自澳大利亚昆士兰州28个长期护理机构的n = 415位年龄≥60岁，被诊断为痴呆症的居民的病历进行回顾性描述性审核，以了解其潜在的药物相互作用。提取的信息包括常规和Pro Re Nata中枢神经系统药物的类型和用法。结果：在服用药物的患者（n = 317）中，有68％的患者处方了至少一种潜在的不适当药物，并且两者之间存在显着的正相关性。处方药的数量以及可能不适当的药物的数量。从130名居住于≥1种药物的居民中发现了200种潜在的严重相互作用，其中38％为潜在的严重相互作用，46％为中度。结论：本次药物审核引起了人们的担忧，即处方药仍可能是治疗行为学的首选手段和痴呆症的心理症状。需要有效和可持续的以人为中心的干预措施，以解决适当处方实践的障碍，并需要所有医疗保健专业人员的合作来优化老年痴呆症患者的处方处方并提高药物质量。

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